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Research papers

ATP-release pannexin channels are gated by lysophospholipids.

Henze E, Ehrlich JJ, Burkhardt RN, Fox BW, Michalski K, Kramer L, Lenfest M, Boesch JM, Schroeder FC, and Kawate T. (2023) bioRxiv 2023.10.23.563601. doi: 10.1101/2023.10.23.563601.


GCP16 stabilizes the DHHC9 subfamily of protein acyltransferases through a conserved C-terminal cysteine motif.

Nguyen PL, Greentree WK, Kawate T, Linder ME. (2023) Front Physiol. 14:1167094. doi: 0.3389/fphys.2023.1167094

The cryo-EM structure of a pannexin 1 reveals unique motifs for ion selection and inhibition

Michalski K, Syrjanen JL, Henze E, Kumpf J, Furukawa H, and Kawate T. (2020) eLife. doi: 10.7554/eLife.54670


CAKUT and Autonomic Dysfunction Caused by Acetylcholine Receptor Mutations.
Mann N, Kause F, Henze EK, Gharpure A, Shril S, Connaughton DM, Nakayama M, Klämbt V, Majmundar AJ, Wu CW, Kolvenbach CM, Dai R, Chen J, van der Ven AT, Ityel H, Tooley MJ, Kari JA, Bownass L, El Desoky S, De Franco E, Shalaby M, Tasic V, Bauer SB, Lee RS, Beckel JM, Yu W, Mane SM, Lifton RP, Reutter H, Ellard S, Hibbs RE, Kawate T, Hildebrandt F. (2019) Am J Hum Genet. 105(6):1286-1293. doi: 10.1016/j.ajhg.2019.10.004.

The weak voltage dependence of pannexin 1 channels can be tuned by N-terminal modifications

Michalski K, Henze E, Nguyen P, Lynch P, and Kawate T. (2018) J Gen Physiol. doi: 10.1085/jgp.201711804

The P2X7 receptor forms a dye-permeable pore independent of its intracellular domain but dependent on membrane lipid composition

Karasawa A, Michalski K, Mikhelzon P, and Kawate T. (2017) eLife, 6:e31186

Structural basis for subtype-specific inhibition of the P2X7 receptor

Karasawa A and Kawate T. (2016) eLife, 5:e22153

Carbenoxolone inhibits Pannexin1 channels through interactions in the first extracellular loop

Michalski K and Kawate T. (2016) J Gen Physiol. 147(2):165-74

Membrane protein mobility and orientation preserved in supported bilayers created directly from cell plasma membrane blebs

Richards MJ, Hsia CY, Singh RR, Haider SH, Kumpf JM, Kawate T, and Daniel S. (2016) Langmuir. 32(12):2963-74.

Reviews, Methods, and Book chapters 

Methods for Studying Cholesterol-Dependent Regulation of P2X7 Receptors.

Murrell-Lagnado RD, Kawate T. (2022) Methods Mol Biol. 2022;2510:253-264. doi: 10.1007/978-1-0716-2384-8_13.

On the molecular nature of large-pore channels.

Syrjanen J, Michalski K, Kawate T, Furukawa H. (2021) J Mol Biol. 433(17):166994. doi: 10.1016/j.jmb.2021.166994.

P2X Receptor Activation

Kawate T. (2017) Adv Exp Med Biol.

Expression and Purification of a Mammalian P2X7 Receptor from Sf9 insect Cells

Karasawa A and Kawate T. (2017) Bio Protoc, Sep 05;7(17)

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